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While uncomfortable, increased cold sensitivity is generally a physiological adaptation to weight loss rather than a concerning adverse reaction

19,351,354 Metabolic syndrome (MetS) and its mechanism Metabolic syndrome is characterized by a cluster of conditions, including obesity, insulin resistance, and dyslipidemia, and is intimately linked to chronic inflammation

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GLP-1 is then degraded by dipeptidyl peptidase IV (DPP-IV) within 5 min after its secretion [9] (Fig